Low Fitness Cost of the Multidrug Resistance Genecfr

Low fitness cost of the multidrug resistance gene cfr.

The recently described rRNA methyltransferase Cfr that methylates the conserved 23S rRNA residue A2503, located in a functionally critical region of the ribosome, confers resistance to an array of ribosomal antibiotics, including linezolid. A number of reports of linezolid-resistant cfr-positive clinical strains indicate the possible rapid spread of this resistance mechanism. Since the rate of ...

Targeting the Achilles Heel of Multidrug-Resistant Cancer by Exploiting the Fitness Cost of Resistance

Exploiting the Fitness Cost of Resistance Gergely Szakaćs,*,† Matthew D. Hall,‡ Michael M. Gottesman,‡ Ahceǹe Boumendjel, Remy Kachadourian, Brian J. Day, Heĺeǹe Baubichon-Cortay, and Attilio Di Pietro* †Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudośok körut́ja 2, Budapest 1117, Hungary ‡Laboratory of Cell Biology, Center for Cancer Res...

Mechanisms of adaptation to the fitness cost of antibiotic resistance

The epidemiological fitness cost of drug resistance in Mycobacterium tuberculosis.

The emergence of antibiotic resistance in Mycobacterium tuberculosis has raised the concern that pathogen strains that are virtually untreatable may become widespread. The acquisition of resistance to antibiotics results in a longer duration of infection in a host, but this resistance may come at a cost through a decreased transmission rate. This raises the question of whether the overall fitne...

Fitness cost of chromosomal drug resistance-conferring mutations.

To study the cost of chromosomal drug resistance mutations to bacteria, we investigated the fitness cost of mutations that confer resistance to different classes of antibiotics affecting bacterial protein synthesis (aminocyclitols, 2-deoxystreptamines, macrolides). We used a model system based on an in vitro competition assay with defined Mycobacterium smegmatis laboratory mutants; selected mut...